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Home addresses were geocoded and linked to modeled outdoor NO2 estimates, as a marker of local traffic-related pollution. Methods: Adults from 13 cities of the second European Community Respiratory Health Survey (ECRHS II) were included (n = 2,920), for whom both DNA and outdoor NO2 estimates were available. OBJECTIVES: We investigated the role of genetic polymorphisms potentially modifying the association between home outdoor levels of modeled nitrogen dioxide and asthma. This points to the importance of antioxidant pathways in the protection against the effects of air pollution on asthma.Ībstract = "BACKGROUND: Traffic-related air pollution is related with asthma, and this association may be modified by genetic factors. CONCLUSIONS: Genetic polymorphisms in the NQO1 gene are related to asthma susceptibility among persons exposed to local traffic-related air pollution. A significant interaction was found between NQO1 rs2917666 and NO2 for asthma prevalence (p = 0.02) and new-onset asthma (p = 0.04). For new-onset asthma, the effect of NO 2 was significant for the most common genotype of NQO1 rs2917666 (OR = 1.52 95% CI, 1.09-2.16).
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RESULTS: The association between modeled NO 2 and asthma prevalence was significant for carriers of the most common genotypes of NQO1 rs2917666, TNFA rs2844484 (OR = 2.02 95% CI, 1.30-3.27). We examined asthma prevalence and evaluated polymorphisms in genes involved in oxidative stress pathways, inflammatory response, immunologic response, and airway reactivity. Home addresses were geocoded and linked to modeled outdoor NO 2 estimates, as a marker of local traffic-related pollution. Methods: Adults from 13 cities of the second European Community Respiratory Health Survey (ECRHS II) were included (n = 2,920), for whom both DNA and outdoor NO 2 estimates were available. BACKGROUND: Traffic-related air pollution is related with asthma, and this association may be modified by genetic factors.